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Scientific Publications

Some examples of previous publications that I have been involved in over the years (as a scientist). Some are published in peer review journals and others have appeared in academic books. The style very much reflects the services I can provide you now as a scientific writer. 

I have tried to provide downloadable versions where available (and as much as I dare to not infringe copyright!).

Gut metabolism and cardioprotective effects of dietary isoflavones.

This review covers the potential role of soya isoflavones in protection from coronary artery disease.  It also looks at a potential role of the human gut microbiota in modifying the potential activities of isoflavones.  It was first published in 2003 in Current Topics in Nutraceutical Research.

Here is the abstract as it appeared in the first issue of Current Topics in Nutraceutical Research:

The Food and Drugs Administration (FDA) has recently approved a health claim for soy based on clinical trials and epidemiological data indicating that a high soy consumption is associated with a lower risk of coronary artery disease. Soy products contain a group of compounds called isoflavones, with genistein and daidzein (and their corresponding glycosides) being the most abundant. Isoflavones undergo extensive metabolism in the gut lumen prior to absorption. The chemical form in which the isoflavones are ingested, the activitity of specific intestinal microflora and the presence of other dietary factors are important determinants of isoflavone metabolism, bioavailability, and subsequent biological activities. Current research has begun to elucidate the species and activities of various bacteria that may be responsible for the metabolism of isoflavones to their more protective secondary metabolites. However underlying molecular mechanisms have not yet been clearly established. A number of cardioprotective benefits have been attributed to dietary isoflavones including a reduction in LDL cholesterol, an inhibition of pro-inflammatory cytokine, cell adhesion protein and nitric oxide production, potential reduction in the susceptibility of the LDL particle to oxidation, inhibition of platelet aggregation and an improvement in vascular reactivity.

The full text is available via this website (publishers)

Here is the full reference with a list of all the authors:

Bingham M, Gibson G, Gottstein N, de Pascual-Teresa S, Minihane AM, Rimbach G (2003).  Gut metabolism and cardioprotective effects of dietary isoflavones.  Current Topics in Nutraceutical Research 1(1): 31-48

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