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Scientific Publications

Some examples of previous publications that I have been involved in over the years (as a scientist). Some are published in peer review journals and others have appeared in academic books. The style very much reflects the services I can provide you now as a scientific writer. 

I have tried to provide downloadable versions where available (and as much as I dare to not infringe copyright!).

Differences between the gut microflora of children with autisitic spectrum disorders and that of healthy children

This project was a prospective study designed to understand if there were any fundamental differences in gut microbiota composition between children with and without autisitic spectrum disorders.  It appeared in the Journal of Medical Microbiology in 2005.

Here is the abstract as it appeared in the Journal of Medical Microbiology:

Children with autistic spectrum disorders (ASDs) tend to suffer from severe gastrointestinal problems. Such symptoms may be due to a disruption of the indigenous gut flora promoting the overgrowth of potentially pathogenic micro-organisms. The faecal flora of patients with ASDs was studied and compared with those of two control groups (healthy siblings and unrelated healthy children). Faecal bacterial populations were assessed through the use of a culture-independent technique, fluorescence in situ hybridization, using oligonucleotide probes targeting predominant components of the gut flora. The faecal flora of ASD patients contained a higher incidence of the Clostridium histolyticum group (Clostridium clusters I and II) of bacteria than that of healthy children. However, the non-autistic sibling group had an intermediate level of the C. histolyticum group, which was not significantly different from either of the other subject groups. Members of the C. histolyticum group are recognized toxin-producers and may contribute towards gut dysfunction, with their metabolic products also exerting systemic effects. Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients.

You can read more about the study here and you can download the original paper here

Here is the full reference with all the authors listed:

Parracho HMRT, Bingham M, Gibson G, McCartney A (2005). Differences between the gut microflora of children with autisitic spectrum disorders and that of healthy children. Journal of Medical Microbiology. 54: 987-991

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